Tuberculosis Host-Pathogen Interactions by Jeffrey D. Cirillo (English) Paperbac

Description: Tuberculosis Host-Pathogen Interactions by Jeffrey D. Cirillo, Ying Kong This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide. Back Cover Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-the-art advances related to our understanding of how this organism causes disease in humans, its mechanisms involved in parasitizing the host, as well as how the host resists or becomes susceptible to infection. We cover several of the molecular, biochemical and structural aspects of the bacterium responsible, Mycobacterium tuberculosis , and describe individual components of the host response and how these impact the course of disease. Although we cover only a very small portion of the field in this overview, we believe that there is a great deal of novel information present that will be valuable to any researcher or student of the field. We are at a stage where there are often more questions than answers, but use of the foundation that is now developing through the effort of tuberculosis researchers provides us with opportunities previously out of reach. This text provides overviews of the field in a number of different areas that will engage researchers interested in tuberculosis, and provide suggestions for ways to move forward. All of the authors hope that readers enjoy this taste of each area, and that their contributions will help others to make additional progress. Dr. Jeffrey D. Cirillo is a Regents Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis. Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis. Author Biography Dr. Jeffrey D. Cirillo is a Regents Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis. Table of Contents 1.Cell Wall Biosynthesis and Latency During Tuberculosis Infections.- 2. The Silent Plague: Regulation of Latent Tuberculosis Infections.- 3. Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis.- 4. Role of Myeloid-derived Suppressor Cells and Regulatory T-cells in the Tuberculous Granuloma.- 5. Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells.- 6. Role of Mycobacterium tuberculosis PE and PPE proteins in pathogen-host interactions.- 7. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy.- 8. Optical In Vivo Imaging in Tuberculosis Research.- 9. Mycobacteria Infection and Lipid Droplets – Host and Pathogen Stealing, Sharing and Storing Fat.- 10. Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve Tuberculosis Control. Review "This is a compendium of reviews covering the basics of tuberculosis pathogenesis and the interaction with the human host. ... This will be useful to seasoned researchers who want a review of the field and to learn about recent advances." (Carlos E Figueroa Castro, Doodys Book Reviews, January 31, 2020) Review Quote "This is a compendium of reviews covering the basics of tuberculosis pathogenesis and the interaction with the human host. ... This will be useful to seasoned researchers who want a review of the field and to learn about recent advances." (Carlos E Figueroa Castro, Doodys Book Reviews, January 31, 2020) Feature Details research and cutting edge technologies, including Mycobacteria infection, in vivo imaging in animals, TB/HIV Polymicrobial Disease, TDM involvement, and more Unique resource focusing on the ever-developing area of host-pathogen interaction in Tuberculosis Provides a broad overview for nearly any clinical or research group, as well as detailed insight into basic research for those already in the field Details ISBN303025383X Pages 255 Year 2020 ISBN-10 303025383X ISBN-13 9783030253837 Publication Date 2020-09-20 Language English Format Paperback UK Release Date 2020-09-20 Edition 1st Place of Publication Cham Country of Publication Switzerland Author Ying Kong Publisher Springer Nature Switzerland AG Edition Description 1st ed. 2019 Imprint Springer Nature Switzerland AG Alternative 9783030253806 Edited by Ying Kong DEWEY 616.079 Audience Professional & Vocational Illustrations 32 Illustrations, color; 1 Illustrations, black and white; VIII, 255 p. 33 illus., 32 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:129896003;

Price: 314.31 AUD

Location: Melbourne

End Time: 2025-01-05T20:16:08.000Z

Shipping Cost: 9.49 AUD