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Transporters in Drug Development : Discovery, Optimization, Clinical Study an...

Description: Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation, Paperback by Sugiyama, Yuichi (EDT); Steffansen, Bente (EDT), ISBN 1493952064, ISBN-13 9781493952069, Brand New, Free shipping in the US Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Th describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and th highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Price: 199.38 USD

Location: Jessup, Maryland

End Time: 2024-12-26T09:51:19.000Z

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Transporters in Drug Development : Discovery, Optimization, Clinical Study an...

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Book Title: Transporters in Drug Development : Discovery, Optimization, Clinical Study and Regulation

Number of Pages: Xiii, 317 Pages

Language: English

Publisher: Springer New York

Publication Year: 2016

Topic: Life Sciences / Molecular Biology, Pharmacy, Pharmacology, Research, Chemistry / Organic

Item Height: 0.7 in

Illustrator: Yes

Genre: Science, Medical

Item Weight: 179.7 Oz

Item Length: 9.2 in

Author: Bente Steffansen

Book Series: Aaps Advances in the Pharmaceutical Sciences Ser.

Item Width: 6.1 in

Format: Trade Paperback

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