Description: Transmethylations and the Central Nervous System Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): V. M. Andreoli, A. Agnoli, C. Fazio Format: Paperback Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN-13: 9783642885181, 978-3642885181 Synopsis V M. ANDREOLl, A. AGNOLI, and C. FAZIO The transfer of a methyl group from a donor to an acceptor compound is a fundamental biochemie al process long since known to biologists; the process is involved, for instance, in the metabolism of porphyrins, nuc1eic acids, and fatty acids. Only recently, however, did transmethylation processes reveal their decisive role in CNS biochemistry - namely with the discovery that such processes are linked with the biogenie amines that have been conc1usively identified as the chemical mediators of neu- ronal transmission and, more broadly, of behavior. The first suggestion that transmethylation processes might be involved in the origina- tion of certain mental diseases came from Harley-Mason [tel], who noticed that many of the hallucinogenic substances known at that time contained methyl radicals, and par- ticularly that mescaline represented the product of O-methylation of dopamine in posi- tions 3, 4, and 5. This hypothesis was put forward when the O-methylation of catechol- amines by catechol-O-methyltransferases had not yet been described. Harley-Mason further proposed that in the living organism the process of O-methyla- tion might follow a "deviant" metabolie pathway, and that the accumulation of abnor- mal methylated metabolites endowed with hallucinogenic properties might be responsi- ble for the implementation of some mental diseases, notably schizophrenia. He also called attention to a substance, 3,4-dimethoxyphenylethylamine (3,4-DMPEA) as a possible psychotogenic moleeule, on the strength of its capacity for producing cata- tonia in experimental animals.
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Book Title: Transmethylations and the Central Nervous System
Number of Pages: 188 Pages
Publication Name: Transmethylations and the Central Nervous System
Language: English
Publisher: Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Item Height: 244 mm
Subject: Psychology, Biology
Publication Year: 2014
Type: Textbook
Item Weight: 349 g
Author: C. Fazio, V. M. Andreoli, A. Agnoli
Item Width: 170 mm
Series: Monographien Aus Dem Gesamtgebiete Der Psychiatrie
Format: Paperback
