The Origin of Amyotrophic Lateral Sclerosis by Michael Hoffmann (English) Paperb

Description: The Origin of Amyotrophic Lateral Sclerosis by Michael Hoffmann Estimated delivery 3-12 business days Format Paperback Condition Brand New Description Each living cell requires energy in form of ATP for most of its processes. This energy is provided within a cell in a compartment that is termed mitochondrion. Within mitochondria, action of the mitochondrial respiratory chain generates the energy using electrons and oxygen. However and because the mitochondrial respiratory chain is so powerful, a side product of ATP is harmful ROS. During physical exercise energy demand increases, which is covered by a raised activity of the mitochondrial respiratory chain. But consequently, the risk of cellular damage inflicted by ROS also increases. To avoid damage done to cellular components, healthy individuals hold capable defense systems against ROS, notably enzymes of the GST, SOD and UCP classes. Of these, the UCP system is particularly noteworthy because of its capability to operate before ROS is generated. This UCP function is achieved by a reduction of the proton gradient across the inner mitochondrial membrane. However, because the proton gradient is coupled to ATP generation, a reduction of this gradient consequently diminishes energy production. This means that a cell has to deliberate whether ROS should be prevented at the cost of its cellular energy levels. But what happens if UCP activity is induced by external events or by exposure to specific substances that evoke a permanent energy deficit? In this book the physiological consequences of enhanced UCP activity are explained and as a result, can be connected to the origin of the neurodegenerative disease amyotrophic lateral sclerosis. Thus, potential treatment opportunities are provided that are missing so far. Further in this context, known risk factors for the initiation of ALS are discussed. Details ISBN 1519549660 ISBN-13 9781519549662 Title The Origin of Amyotrophic Lateral Sclerosis Author Michael Hoffmann Format Paperback Year 2015 Pages 62 Publisher Createspace Independent Publishing Platform GE_Item_ID:130050783; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys

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