The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease: Cushing's Syndrom

Description: The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease by Eliza B. Geer The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushings syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushings remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states. Back Cover Cushings syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states." Author Biography Eliza B. Geer, MD is an endocrinologist at Mount Sinai Medical Center in the Division of Endocrinology with a secondary appointment in the Department of Neurosurgery. After graduating from Columbia University, she attended Mount Sinai School of Medicine, graduating in 2006. Dr. Geers clinical and research interests include pituitary diseases and neuroendocrinology. She is the principal investigator of a number of studies investigating body composition, adipose tissue regulation, appetite, and long term outcomes in patients with Cushings Disease and other pituitary diseases. She was awarded the Dr. Harold and Golden Lamport Research Award for Clinical Research in 2012, and the Mount Sinai Endocrinologist of the Year award for outstanding service to the Icahn School of Medicine and Mount Sinai Hospital in 2013. Table of Contents Part 1. Hypothalamic-pituitary-adrenal axis regulation of the body, brain, and inflammation.- 1. Glucocorticoid regulation of body composition and metabolism.- 2. Glucocorticoid regulation of neurocognitive and neuropsychiatric function.- 3. Glucocorticoids: Inflammation and Immunity.- Part 2. Cushings Syndrome.- 4. Pathogenesis, diagnosis and localization of Cushings: Molecular pathogenesis of primary adrenal Cushings syndrome .- . 5. Pathogenesis, diagnosis and localization of Cushings.- 5. Pathogenesis, diagnosis and localization of Cushings: Pathogenesis and treatment of aggressive corticotroph pituitary tumors - Yang Shen and Anthony P Heaney.- 6. Pathogenesis, diagnosis and localization of Cushings: Neoplastic/Pathologic and Non-neoplastic/Physiologic Hypercortisolism: Cushing verses Pseudo-Cushing Syndromes.- 7. Pathogenesis, diagnosis and localization of Cushings: Imaging strategies for localization of ACTH - secreting tumors.- 8. Recent Advances in the medical andsurgical treatment of Cushings: Surgical Treatment of Cushings disease.- 9. Recent Advances in the medical and surgical treatment of Cushings: Medical therapies in Cushings syndrome.- 10. New themes in Cushings definitions and outcomes: Mild adrenal cortisol excess – 11. New themes in Cushings definitions and outcomes: Long term effects of prior Cushings syndrome .- 12. New themes in Cushings definitions and outcomes: Cushings disease: refining the definition of remission and recurrence.- Part 3. Beyond Cushings: Glucocorticoid sensitivity, regulation and the metabolic syndrome.- 13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis through a Mutated Glucocorticoid Receptor.- 14. Cortisol metabolism as a regulator of the tissue-specific glucocorticoid action.- 15. Obesity and metabolic syndrome: a phenotype of mild long-term hypercortisolism. Feature Explores recent advances in the development of novel medical therapies for the treatment of Cushings syndrome Provides valuable and cutting edge perspectives on these topics including the concept of "subclinical" adrenal Cushings syndrome Reviews the pathophysiology of excess cortisol on body composition and metabolism, in particular adipose tissue and bone Details ISBN3319459481 ISBN-10 3319459481 ISBN-13 9783319459486 Format Hardcover Year 2016 Pages 327 Publication Date 2016-12-16 Language English Media Book Edition 1st Imprint Springer International Publishing AG Place of Publication Cham Country of Publication Switzerland Edited by Eliza B. Geer Illustrations 15 Illustrations, color; 4 Illustrations, black and white; VI, 327 p. 19 illus., 15 illus. in color. Short Title The Hypothalamic Pituitary Adrenal Axis in Health and Disease Author Eliza B. Geer Birth 1958 Affiliation Marquette University, Wisconsin Position EDFR Qualifications M.D. Publisher Springer International Publishing AG Edition Description 1st ed. 2017 Subtitle Cushings Syndrome and Beyond Alternative 9783319834054 DEWEY 616.4 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131027099;

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