Parent-of-origin Effect in Families of Bipolar Disorder: Evidence from Three Kin

Description: Parent-of-origin Effect in Families of Bipolar Disorder by Tsuo-Hung Lan Bipolar disorder is a chronic psychiatric disease characterized by swinging pathologic mood changes and potentially devastating impact on social functioning with an estimated 1% life prevalence in United States. Twin, adoption, and family studies have supported the role of a genetic component in the pathogenesis of bipolar disorder. In this book, three different approaches (segregation analysis, IBD analysis, and TDT analysis) were applied to test for heterogeneity between two subgroups defined by parental lineality of disease transmission. These three lines of evidence support heterogeneity of bipolar disorder between families with different parental transmission linearity. They also confirm previously suspected parent-of-origin phenomenon and suggest a possible way to enhance the prevention, diagnosis, and treatment of bipolar disorder in public health by incorporating this idea into further approaches. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Bipolar disorder is a chronic psychiatric disease characterized by swinging pathologic mood changes and potentially devastating impact on social functioning with an estimated 1% life prevalence in United States. Twin, adoption, and family studies have supported the role of a genetic component in the pathogenesis of bipolar disorder. In this book, three different approaches (segregation analysis, IBD analysis, and TDT analysis) were applied to test for heterogeneity between two subgroups defined by parental lineality of disease transmission. These three lines of evidence support heterogeneity of bipolar disorder between families with different parental transmission linearity. They also confirm previously suspected parent-of-origin phenomenon and suggest a possible way to enhance the prevention, diagnosis, and treatment of bipolar disorder in public health by incorporating this idea into further approaches. Author Biography Tsuo-Hung Lan, finished his psychiatrist training in Taipei Veterans General Hospital in 1996 after graduation from National Yang-Ming University, Taiwan. Then he got his PhD degree in Johns Hopkins University in 2002. His major research topics is focusing on pharmacogenetics of schizophrenia by using neural network model in recent years. Details ISBN3639107934 Author Tsuo-Hung Lan Short Title PARENT-OF-ORIGIN EFFECT IN FAM Pages 344 Publisher VDM Verlag Language English ISBN-10 3639107934 ISBN-13 9783639107937 Media Book Format Paperback Year 2009 Subtitle Evidence from Three Kinds of Genetic Statistical Methods Publication Date 2009-07-30 UK Release Date 2009-07-30 Imprint VDM Verlag Country of Publication Germany Illustrations black & white illustrations Audience General We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:132587179;

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