Description: Nonsense-Mediated mRNA Decay in Human Disease: An Approach for Personalized Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). . It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
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EAN: 9780128044681
UPC: 9780128044681
ISBN: 9780128044681
MPN: N/A
Item Length: 22.6 cm
Item Height: 229 mm
Item Width: 152 mm
Author: Hana Benhabiles, Jieshuang Jia, Fabrice Lejeune
Publication Name: Nonsense Mutation Correction in Human Diseases: an Approach for Targeted Medicine
Format: Paperback
Language: English
Publisher: Elsevier Science Publishing Co Inc
Subject: Biology
Publication Year: 2016
Type: Textbook
Item Weight: 320 g
Number of Pages: 190 Pages
