New CarbonCarbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed

Description: New CarbonCarbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed CH Activation by Rui Shang This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation. The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner. Back Cover This thesis presents the latest developments in new catalytic C-C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C-H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation. The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C-C bonds to access valuable chemicals. In turn, the second part is devoted to several new C-C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C-H bond as the coupling partner. Table of Contents Introduction to Carbon-Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C-H Activation.- Part I New Carbon-Carbon Bond Formation Methodologies Based on Decarboxylation.- Transition-Metal-Catalyzed Decarboxylation and Decarboxylative Cross-Couplings.- Palladium-Catalyzed Decarboxylative Coupling of Potassium Oxalate Monoester with Aryl and Alkenyl Halides.- Synthesis of Polyfluorobiaryls via Copper-Catalyzed Decarboxylative Couplings of Potassium Polyfluorobenzoates with Aryl Bromides and Iodides.- Palladium-Catalyzed Decarboxylative Couplings of Potassium Polyfluorobenzoates with Aryl Bromides, Chlorides and Triflates.- Construction of C(sp3)-C(sp2) Bonds via Palladium-Catalyzed Decarboxylative Couplings of 2-(2-Azaaryl)acetate Salts with Aryl Halides.- Synthesis of α-Aryl Nitriles and α-Aryl Acetate Esters via Palladium-Catalyzed Decarboxylative Couplings of α-Cyano Carboxylate Salts and Malonate Monoester Salts with Aryl Halides.- Palladium-Catalyzed Decarboxylative Couplings of Nitrophenyl Acetate Salts and Its Derivatives with Aryl Halides.- Palladium-Catalyzed Decarboxylative Benzylation of α-Cyano Aliphatic Carboxylate Salts with Benzyl Electrophiles.- Part II New Carbon-Carbon Bond Formation Methodologies Based on Iron-Catalyzed C-H Activation.- Recent Develpments of Iron-Catalyzed Directed C-H Activation/C-C Bond Formation Reactions.-β-Arylation of Carboxamides via Iron-Catalyzed C(sp3)–H Bond Activation.- Iron-Catalyzed C(sp2)–H and C(sp3)–H Bond Functionalization with Organoboron Compounds. Feature Nominated as an outstanding PhD thesis by the University of Science and Technology of China Highlights a series of highly efficient decarboxylative coupling reactions that will be of interest to synthetic chemists Presents several inexpensive and user-friendly carboxylate salts that offer useful coupling reagents to access valuable chemicals, including drug intermediates Explores the unknown reactivity of iron as a catalyst and presents step-efficient C-H coupling reactions to form C-C bonds using the sustainable catalyst iron Winner of the Chinese Academy of Sciences 100 Excellent Doctoral Dissertation Award (2015) Details ISBN9811098131 Author Rui Shang Series Springer Theses Year 2018 ISBN-10 9811098131 ISBN-13 9789811098130 Format Paperback DEWEY 541.2 Pages 216 Publisher Springer Verlag, Singapore Publication Date 2018-07-05 Imprint Springer Verlag, Singapore Place of Publication Singapore Country of Publication Singapore Language English UK Release Date 2018-07-05 Illustrations 7 Illustrations, color; 156 Illustrations, black and white; XVII, 216 p. 163 illus., 7 illus. in color. Edition Description Softcover reprint of the original 1st ed. 2017 Alternative 9789811031922 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:131043061;

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