Description: Development of New Radical Cascades and Multi-component Reactions : Application to the Synthesis of Nitrogen-containing Heterocycles, Paperback by Larraufie, Marie-helene, ISBN 3319377868, ISBN-13 9783319377865, Brand New, Free shipping in the US In this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact clarity and depth of the experimental section will be useful for students and researchers working in this field.
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Book Title: Development of New Radical Cascades and Multi-Component Reactions : Application to the Synthesis of Nitrogen-Containing Heterocycles
Number of Pages: Xxii, 326 Pages
Language: English
Publisher: Springer International Publishing A&G
Topic: Physics / Quantum Theory, Chemistry / Physical & Theoretical, Chemistry / Organic
Publication Year: 2016
Item Height: 0.7 in
Illustrator: Yes
Genre: Science
Item Weight: 25.3 Oz
Author: Marie-Helene Larraufie
Item Length: 9.2 in
Book Series: Springer Theses Ser.
Item Width: 6.1 in
Format: Trade Paperback
