Behavioral Neurobiology of the Endocannabinoid System by Dave Kendall (English)

Description: Behavioral Neurobiology of the Endocannabinoid System by Dave Kendall, Stephen Alexander The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. The?rstpartprovidesabackgroundand"toolbox",detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey in?uencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourettessyndrome.Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor...65 IstvanKatona 4 PharmacologicalToolsinEndocannabinoidNeurobiology...87 MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem ...111 KrisztinaMonoryandBeatLutz 6 EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7 LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII PhysiologyandPathophysiology 8 RolesoftheEndocannabinoidSysteminLearning andMemory ...201 GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9 EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231 TimC.Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11 TargetingtheCannabinoidSystemtoProduceAnalgesia ...275 DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12 IntegrationofEndocannabinoidSignalingintotheNeural NetworkRegulatingStress-InducedActivationofthe Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB. GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309 ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14 RoleofEndocannabinoidSignalinginAnxietyandDepression...347 SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373 CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto 16 Schizophrenia...387 F. Markus 17 TourettesSyndrome...397 KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H. Alexander SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN- tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201, USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and Center of Applied Biomedical Research (C.R. B. A. ), DepartmentofInternalMedicineandGastroenterology,S. Orsola-MalpighiHos- tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy VictoriaChapman SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH, UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments of Pharmacology, Pediatrics and Cell & Developmental Biology, Division of Reproductive and Developmental Biology, Vanderbilt University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt. edu StevenR. Back Cover The endocannabinoid signalling system is one of the key modulators of central nervous function. This volume provides timely and in-depth coverage of the roles of the endocannabinoid signalling system in the neurobiology of behavior. It is essential reading for any researcher with a background in neuroscience wanting to know more about the endocannabinoids. The first section provides a comprehensive account of the component parts of the system (the signalling molecules, synthetic and degradative enzymes and receptors), their location within the central nervous system and the endocannabinoids roles in neural plasticity. This section also describes the toolboxes (genetic and pharmacological) used to study the system. The second section concentrates on endocannabinoid function in the control of normal physiological behaviors including a reference to the evolution of the system based on its operation in non-mammalian vertebrates. The volume concludes by addressing the importance of the endocannabinoids in pathological behaviors including affective and cognitive disorders, neurodegenerative conditions, feeding and drug abuse. Table of Contents Biochemistry, Pharmacology, Genetics & Chemistry.- The Life Cycle of the Endocannabinoids: Formation and Inactivation.- Endocannabinoid Receptor Pharmacology.- Endocannabinoid Receptors: CNS Localization of the CB1 Cannabinoid Receptor.- Pharmacological Tools in Endocannabinoid Neurobiology.- Genetic Models of the Endocannabinoid System.- Endocannabinoid Signaling in Neural Plasticity.- Lessons from Nonmammalian Species.- Physiology and Pathophysiology.- Roles of the Endocannabinoid System in Learning and Memory.- Endocannabinoids and the Non-Homeostatic Control of Appetite.- Cannabinoid/Endocannabinoid Signaling Impact on Early Pregnancy Events.- Targeting the Cannabinoid System to Produce Analgesia.- Integration of Endocannabinoid Signaling into the Neural Network Regulating Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis.- Pathology.- Drug Addiction.- Role of Endocannabinoid Signaling in Anxiety and Depression.- Feeding Disorders and Obesity.- Schizophrenia.- Tourettes Syndrome. Long Description Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersintheeld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. Therstpartprovidesabackgroundand"toolbox",detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey inuencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. Thenalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourettessyndrome. Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstotheeld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 Istva Feature Includes supplementary material: sn.pub/extras Details ISBN3642260780 Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Series Current Topics in Behavioral Neurosciences Year 2012 ISBN-10 3642260780 ISBN-13 9783642260780 Format Paperback Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Edited by Stephen Alexander Short Title BEHAVIORAL NEUROBIOLOGY OF THE Language English Media Book Series Number 1 Pages 420 Edition 2009th Publication Date 2012-03-14 Author Stephen Alexander Edition Description 2009 ed. Alternative 9783540889540 DEWEY 610 Audience Professional & Vocational Illustrations 10 Illustrations, color; XII, 420 p. 10 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96371112;

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