Description: Anticancer Drug Development Guide Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Preclinical Screening, Clinical Trials, and Approval Author(s): Beverly A. Teicher, Paul A. Andrews Format: Paperback Publisher: Humana Press Inc., United States Imprint: Humana Press Inc. ISBN-13: 9781468498417, 978-1468498417 Synopsis This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
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Book Title: Anticancer Drug Development Guide
Number of Pages: 451 Pages
Language: English
Publication Name: Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval
Publisher: Humana Press Inc.
Publication Year: 2012
Subject: Medicine
Item Height: 254 mm
Item Weight: 883 g
Type: Textbook
Author: Paul A. Andrews, Beverly A. Teicher
Series: Cancer Drug Discovery and Development
Item Width: 178 mm
Format: Paperback
